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(2) reduce clearance rate due to slowed metabolism and renal filtration (131)

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16 More recently, the FLOW trial enrolled 3,533 patients with T2D and CKD (estimated glomerular filtration rate [eGFR] 5075 ml/min/1.73 m 2 with an albumin-to-creatinine ratio of 3005,000 or eGFR 2549 ml/min/1.73 m 2 with an albumin-to-creatinine ratio of 1005,000)

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and Katsilambros, N., Effect of long-term hydroxytyrosol administration on body weight, fat mass and urine metabolomics: a randomized double-blind prospective human study