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Experimental models show GLP-1 receptor activation enhances synaptic plasticity and reduces microglial activation

Gastrointestinal modulation: The medication slows gastric emptying meaning food stays in the stomach longer leading to prolonged fullness and reduced meal frequency

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Although the purpose of the study was not to conduct quantitative analyses, questionnaire data showed a trend towards reduction in PHQ-9, GAD-7 and EDE-Q scores (Table 1), which were clinically significant given that change scores of 5, 4 and 0.57 are considered the minimal clinically important differences in PHQ-9, GAD-7 and total EDE-Q scores respectively [3840]

Comprehensively prognostic and immunological analyses of GLP-1 signaling-related genes in pan-cancer and validation in colorectal cancer