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Weight Loss (Obesity) Drug:Average weight loss Semaglutide:~1215% body weight Tirzepatide:~20% body weight Clinical trials show tirzepatide produced ~50 lbs weight loss vs ~33 lbs with semaglutide in some studies 3.Safety & Side Effects Common side effects for both: Nausea Vomiting Diarrhea Constipation Reduced appetite 4.Cardiovascular Benefits Semaglutide currently has stronger CV outcome data

Start tirzepatide 7 days after your last semaglutide dose

If you are escalating your dose during this period, expect a temporary return of heightened sensitivity with each increase

Mounjaro headaches Headaches are a common Mounjaro side effect and are most often linked to reduced food intake, dehydration, or changes in blood sugar, particularly when starting treatment or after a dose increase

OR28-4 Efficacy and Safety of Tirzepatide Versus Semaglutide in a Hispanic or Latino Population: A Prespecified Subgroup Analysis of SURPASS-2