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Long-term considerations and what to expect after the adjustment period Once you survive the initial adjustment, what comes next

This could be because a lack of sleep decreases leptin (the hormone that signals fullness) and increases ghrelin (the hormone that boosts appetite), triggering cravings for more carbohydrates and overeating

MASH treatment trials

Retatrutide is an investigational triple receptor agonist still in phase 3 clinical trials, whilst sermorelin is an unlicensed growth hormone-releasing peptide in the UK

Conclusions This case is among the few cases in the literature describing life-threatening, ICU-level complications of tirzepatide overdose and highlights the potential for critical illness