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15 , 16 Interestingly, the improvements in quality of life occurred independent of the degree of weight loss, possibly suggesting these improvements are from mechanisms beyond weight reduction alone

Published phase 2 data provide preliminary signals regarding tolerability in research cohorts, but these are not sufficient to establish a safety profile adequate for approved use

Future uses of GLP-1 may also include the treatment of obesity, as well as the adjunctive treatment of type 1 diabetes mellitus in combination with insulin.5 Natural GLP-1 degrades within 23 min in circulation, thus greatly limiting its effects

doi: 10.1016/j.arr.2019.100936

That is more than any approved weight loss drug has produced in a comparable timeframe