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Method We systematically searched PubMed and Embase from inception to 1 May 2025 for cohort studies comparing the effect of combination therapy with SGLT2 inhibitor or GLP-1 RA monotherapy on (cardiovascular) mortality and cardiovascular or kidney endpoints in individuals with type 2 diabetes

Discover top diabetes weight loss drugs, how they work, and who can benefit

Trial registration www.anzctr.org.au ACTRN12621000878875 Funding The study was not funded by a specific research grant

PMCID: PMC10933338
