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In one prospective study, greater than 10% weight loss led to regression in liver fibrosis with greater than 5% weight loss reducing hepatic steatosis

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Another report showed that sitagliptin (576 mg/kg) reduced plaque macrophage infiltration and matrix metallopeptidase-9 (MMP-9) levels in ApoE / mice [26] and increased activation of AMPK and AKT signaling pathway but inhibited MAPK and ERK1/2 signaling in aorta of ApoE / mice [66]

AGA does not endorse all patients stopping popular diabetes and weight loss drugs prior to endoscopy

This article clarifies who should avoid GLP-1 medications, necessary screening, and alternative treatment options for high-risk patients