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If side effects become troublesome at your current dose, your provider can pause your dose increase or lower your dose rather than fragmenting the injection schedule

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It wasnt common for me to take patients who were unresponsive to the most aggressive weight loss therapies (including bariatric surgery), put them on these medications, and watch them lose weight

A few mechanisms that don't reduce neatly to mesolimbic dopamine: (1) conditioned aversion, GLP-1 activation engages nausea/malaise circuits, so some of the reduction in substance use may reflect aversive conditioning rather than reward modulation per se

I have been using Ozempic since the fall of 2020 however I have only succeeded by changing everything else with it