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Stage 1 includes individuals with higher risk of developing dysglycaemia (defined based on validated country-specific risk scores than those with stage 0 or normal -cell function, whose high insulin resistance would be compensated by increased insulin production and glucose remains near normal despite gradual minimal decline in -cell function or mass

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Indications Hypertension first-line or add-on therapy Diabetic nephropathy especially in type 2 diabetes with proteinuria Heart failure for patients intolerant of ACE inhibitors Post-myocardial infarction reduces morbidity and mortality 3