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In an animal study, inhibition of the NF-B pathway led to a significant reduction in the expression of serum proinflammatory cytokines, including IL-6, IL-1 and TNF-, as well as an increase in the expression of the tight junction proteins occludin and ZO-1, thereby improving the function and structure of the intestinal mucosa

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In this regard, it is interesting that IgG antibodies that show similar FcRn binding properties can have variable plasma half-lives due to differences in biophysical properties, such as pI and net charge, which affect cellular handling 83,84,85,86,87

J Biol Chem1986 Sep 5;261(25):11880-9

[DOI] [PubMed] [Google Scholar] 52.Klingberg E., Bilberg A., Bjorkman S., Hedberg M., Jacobsson L., Forsblad-dElia H., Carlsten H., Eliasson B., Larsson I