retatrutide phase 2 nejm 2023 percent weight loss 48 weeks Results: 24% in Retatrutide vs Wegovy: which works
Description
It will be difficult to engineer balanced agonism into a single small-molecule because the sequence hybridisation of the dual and triple peptide agonists has no obvious chemical analogue
-1 2
Because the study population was pooled across the three data sources, a small percentage of overlap between the populations in the different data sources was possible
2020;159(6):2092e1005
Clinical trials show up to 24% weight loss with Retatrutide compared to lower percentages with single-receptor medications, plus better muscle retention and potentially fewer side effects
