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Appetite shifts often occur before weight loss becomes noticeable, especially during the first few weeks

The SURPASS phase 3 clinical trial programme explored the efficacy and safety of tirzepatide in people with type 2 diabetes, and demonstrated dose-dependent reductions in HbA 1c of 2028 mmol/mol in those treated with tirzepatide: greater reductions than those achieved with semaglutide (Fras et al, 2021), insulin degludec (Ludvik et al, 2021) and insulin glargine (Del Prato et al, 2021), with reductions sustained up to 2 years in SURPASS-4

Choosing the best day of the week for your injection helps establish a consistent routine

Participants first lost weight during a 36-week lead-in period on tirzepatide, then were randomized to either continue the medication or switch to placebo for an additional 52 weeks

If you prep on Sundays, injecting Friday or Saturday means your appetite is naturally reduced during your prep day, which may actually help you make better food choices and prepare more appropriate portions