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The first reported GLP-1/GIP co-agonists, which had prolonged half-lives due to the use of fatty acylation or PEGylation, yielded synergistic effects, lowering body weight in obese rodents relative to the individual mono-agonist comparators [465] and having a greater insulinotropic effect in non-human primates

In this study, we found that AMPK activation attenuated the PA-induced reduction of PKA phosphorylation in HUVECs

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