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Results confirmed liraglutide's superiority: HbA1c reduction: -1.48% (liraglutide) vs -1.28% (exenatide ER) Weight loss: -3.57 kg (liraglutide) vs -2.68 kg (exenatide ER) Weight Loss Comparison# Exenatide (DURATION Program)# Exenatide was developed for type 2 diabetes, not weight management: DURATION-1: 3.7 kg weight loss with Bydureon over 30 weeks DURATION-5: 2.3 kg weight loss over 24 weeks Three-year extension: 2.3 kg sustained weight reduction No FDA approval for chronic weight management Liraglutide (SCALE Program)# Liraglutide was specifically developed for obesity at the higher 3.0 mg dose: SCALE Obesity and Prediabetes (Pi-Sunyer et al., NEJM 2015): 8.0% mean weight loss at 56 weeks 63.2% achieved 5% or more weight loss

This is often due to peripheral vasoconstriction, where the body pulls blood away from the skin to protect the core

Mounjaro may provide slightly greater weight loss at the highest dose, but cost and long-term approvals are still evolving

Return of Cravings Appetite-regulating hormones surge back quickly

Clinical trials show average weight loss of 15% to 21% of body weight over 1218 months with the highest doses