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Allison S, Timmerman GM

Because of the ever-expanding use of GLP-1 receptor agonists, the availability of an oral agent within this therapeutic class has the potential to further increase GLP-1 receptor agonist use and provide an alternative route of administration for patients unable or unwilling to take SC injections

Gonadal steroids can also influence GLP-1R expression in the brain and other tissuesin the whole hypothalamus, for example, the highest GLP-1R expression is found in the late proestrus stage (46), providing further mechanistic support for potentially higher sensitivity to GLP-1 effects during this phase of the cycle (33, 47)

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Role of Inflammasomes in Multiple Sclerosis and Their Potential as Therapeutic Targets