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Sequential initiationadding one agent, allowing 48 weeks for tolerance to develop, then introducing the secondmay improve tolerability, particularly regarding gastrointestinal side effects from GLP-1 receptor agonists

Calcium is also known to play an important role in neuronal plasticity and neurodegenerative diseases

Evidence-Based Treatment Many top programs now offer GLP-1 medications such as: semaglutide tirzepatide Wegovy Zepbound These medications should only be prescribed after medical evaluation and provider review

I also question the comparison of GLP-1 weight loss medications to non-GLP-1 weight loss medications because most of the medications in non-GLP-1 classes work to alter brain chemistry and would be much more likely to induce new or worsening symptoms of anxiety and depression

Accessed May 24,2012 Liddle RA