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Therefore, it was concluded that clinically significant pharmacokinetic changes are unlikely to occur.148,167 Similarly, alterations in the pharmacokinetics after 1.8 mg liraglutide and 1.5 mg dulaglutide administration have also been shown to have minimal clinical significance.161,168 The most significant pharmacokinetic alterations were reported following the administration of a single 5 mg dose of tirzepatide, with the C max and AUC values of ethinylestradiol decreasing by 59% and 21%, respectively, and those of norelgestromin by 55% and 22%, respectively (Table 4).161 However, the pharmacokinetic /pharmacodynamic relationship of oral contraceptives is not yet fully defined

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