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The development of multi-agonists with multi-organ targets may alter the natural history of these diseases

Over a relatively short period, obesity and type 2 diabetes have come to represent a large medical and economic burden to global societies

While our current treatments have shown significant therapeutic benefits, there still appear to be some patients who, despite aggressive therapy, good adherence, and inhaler technique, continue to have exacerbations

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Because Medicare patients often face overlapping risks such as chronic kidney disease and cardiovascular complications, multi-indication agents such as the SGLT2s remain an important complementary option alongside GLP1s