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The average patient enrolled in pivotal trials experienced approximately 15% body weight loss compared to 2.4% in placebo groups

Moreover, the MS/MS analysis revealed that the observed molecular weights of the y 3+ , y 4+ , y 5+ , and y 6+ fragments were consistent with the predicted values (Table S3), proving that the OspR effectively catalyzes the modification of the two C-terminal arginine residues in the Sem-2A core peptide, accurately introducing ornithine at the designated positions

For patients who want to address a significant amount of loose or sagging skin, surgical treatment is usually the most effective option for achieving a more refined body shape

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