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The patient should continue semaglutide while initiating first-line RLS treatment with alpha-2-delta ligands (gabapentin, gabapentin enacarbil, or pregabalin...
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The proposed mechanism: the leucine substitution increases hydrophobicity, potentially stabilizing the signal peptide and improving receptor trafficking to the cell surface meaning more receptor, more drug response
Tirzepatide is a GLP-1/GIP receptor agonist that la...
