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These benefits likely arise through a combination of weight-mediated and weight-independent mechanisms, including natriuresis, improved vascular function, and autonomic modulation

LigandScout provided a pharmacophore fit score for each screened molecule

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doi:10.1056/NEJM198805123181902 14

doi: 10.1111/bcp.14855 34 YangWSLeeWJFunahashiTTanakaSMatsuzawaYChaoCLet al
