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Consistent with this, exendin-P5, which induces faster kinetics in G protein activation and cAMP production, exhibits higher cAMP efficacy than GLP-1 and exendin-4, as indicated by a greater pEC 50 /pIC 50 ratio when comparing cAMP and binding studies 13

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To realize their full therapeutic potential, future research must rigorously address several critical dimensions, which collectively form a roadmap for the field