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Human clinical trials on this specific pathway are still underway

The strongest risk factor for CVD and mortality in T2D is diabetic kidney disease (DKD) and DKD has been proposed to account for the majority of CVD risk observed in people with diabetes

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Further economic burden can also be attributed to the substantial indirect costs associated with obesity including those related to absenteeism, presenteeism (reduced productivity at work), short- and long-term disability, premature mortality and worker compensation [17,19]

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