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Safety concerns include gastrointestinal issues, potential aspiration risk, and rare anaphylactic reactions

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Patients with T2DM initiating GLP-1 RAs or metformin as first-line monotherapy were included (87,229 matched patients per cohort).The researchers found that compared with metformin, GLP-1 RA use was associated with a significantly lower risk for overall dementia, Alzheimer disease, and nonvascular dementias (adjusted hazard ratios, 0.90, 0.88, and 0.75, respectively)

Chang, M

How GLP-1 Affects Weight Loss The benefits of GLP-1 for weight management stem from its multifaceted action: Enhanced Satiety: GLP-1 helps increase feelings of fullness after eating