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There was a trend towards an increase in IL-6 after GE2 treatment in WD fed compared to SD fed in males ( p = 0.059, Cohens d =1.509

These changes induce a greater release of intracellular calcium given the high concentrations of estradiol, inducing a greater release of insulin into the bloodstream, contributing to sustained hyperinsulinemia

This prolongs the feeling of fullness after meals, making you less likely to overeat or crave food between meals

They found that AOD9604 increased the number and activity of a specific receptor on fat cells called the beta-3 adrenergic receptor (3-AR), which acts like an on switch for fat burning

One of the most important function of GLP-1 is to act as an incretin by stimulating glucose-dependent release of insulin from pancreatic -cells 3,4,5 while suppressing glucagon secretion by -cells 6 , in response to food ingestion