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There were no animal studies or even basic physiology suggesting they would be helpful for the cardiovascular system. In 2008, the FDA ordered a series of cardiovascular outcomes trials after two studies suggested lowering blood sugar could be dangerous for the heart in patients with type 2 diabetes, Nauck said

Article Information Acknowledgments The authors thank Stephen Purver (Spirit Medical Communications Group Ltd.) for assistance with medical writing and editorial support

In May 2026, At the EASL Congress 2026, MetaVia presented promising late-breaking Phase 1 clinical trial results for DA-1726, an investigational dual GLP-1 and glucagon receptor agonist under development for obesity and Metabolic Dysfunction-Associated Steatohepatitis (MASH)

Preclinical work shows GLP-1 receptor activity in the mesolimbic dopamine pathway, which regulates reward and reinforcement