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Methods We administered male rats with intraperitoneal (i.p.) or intracerebroventricular (i.c.v.) GLP-1R agonist (exendin-4) or antagonist (exendin-9-39) followed by in vivo determination of CSF dynamics

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Our volumizing complex comprised of next generation hyaluronic acid, biomimetic collagen fragments, bakuchiol plus amino acids works synergistically to improve skin impacted by GLP-1 induced facial volume loss and skin texture decline by addressing the appearance of deflation, loose, sagging, crepey skin texture, dehydration, and wrinkles

Weight gain during tirzepatide treatment can occur due to dose adjustments, metabolic adaptation, or individual peptide-pathway responses

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