zepbound glp 1 agonist GLP-1 Agonists in Perimenopause: Unique Risks and Potential Opportunities Tirzepatide (Zepbound)

Emerging clinical observations in humans suggest that GLP-1 medications may help address underlying inflammatory processes in conditions like rheumatoid arthritis, though more research is needed in this area

Due to body habitus, neither magnetic resonance imaging (MRI) nor lumbar puncture was possible to obtain

Randomisation and Study Treatment Participants were randomised in a 1:1 ratio to either active treatment with exenatide (Byetta) or placebo using a computer-generated randomisation list compiled by the Birmingham Clinical Trials Unit

10.7150/thno.45192 [DOI] [PMC free article] [PubMed] [Google Scholar] Fan Y., Liu K., Wang Q., Ruan Y., Ye W., Zhang Y

Limitations Not yet FDA-approved (as of 2025)