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Given the role of vascular dysfunction with both myocardial dysfunction and impaired exercise capacity in HFpEF 54 , and the known expression of GLP-1 receptors in the vasculature, we hypothesized that the weight loss-independent actions of semaglutide in HFpEF might involve improved vascular function

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BP: 120/90 mmHg PR: 80 bpm SpO: 99% GCS: E4VaphonicM6 Pupils: B/L 3mm, reacting to light Systemic Examination: CVS: S1S2 heard, no murmur

42% male / 58% female)