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Additional considerations include genital mycotic infections (yeast infections), which occur more frequently with SGLT2 inhibitors due to elevated urine glucose, and acute kidney injury in rare cases if dehydration becomes severe

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Theyre mathematically linked by: G = RT ln(Kd) Example Suppose you have two drug candidates, A and B, targeting the same protein: - Drug A: Kd = 10^-9 M (1 nM), G = -12.8 kcal/mol - Drug B: Kd = 10^-6 M (1 M), G = -8.6 kcal/mol - Drug A has a lower Kd and more negative G, indicating higher binding affinity and stronger, more stable binding

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Maintain adequate hydration as advised by your healthcare provider