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E., Rasmussen, S., Vilsbll, T., Wolthers, B., & Perkovic, V

In a pilot trial evaluating 104 amnestic MCI and early-stage AD patients, 20 IU and 40 IU doses of intranasal insulin improved Alzheimers Disease Assessment Scale-Cognitive subscale (ADAS-Cog 12) scores compared to placebo-treated patients, with improvements in delayed recall observed 2 months following cessation of treatment in the 20 IU group

Collectively, the current data suggest that metyrapone can be used to promptly normalize hypercortisolaemia and improve cortisol-related metabolic comorbidities in CD patients

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