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As a result, many members turned to diabetes-indicated GLP-1s off-label, creating shortages that impacted patients who needed them for type 2 diabetes
Meanwhile, Eli Lilly is advancing orforglipron, the first small-molecule GLP-1 receptor agonist for obesity
Additionally, GLP-1 receptor activation improves insulin secretion and decreases glucagon secretion in a glucose-dependent manner, helping to stabilize blood sugar levels
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