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As in the previous recommendations by the ADA and EASD (73, 74), life-style intervention (with patient education and motivation, increase of physical activity, and healthy eating) is still in the beginning and center of therapy, followed by pharmacological therapy with metformin (7074)

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[DOI] [PubMed] [Google Scholar] 646.Kumarathurai P., Anholm C., Fabricius-Bjerre A., Nielsen O.W., Kristiansen O., Madsbad S

therefore, it is conceivable that the use of GLP-1RAs may be beneficial in these patients groupsalthough no studies have specifically assessed these mechanistic aspects in relation to psychopathology in humans thus far