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SM significantly induced -endorphin expression and activated p38 mitogen-activated protein kinase signaling in the spinal dorsal horn and primary microglia

Advise patients on the symptoms of hypersensitivity reactions and instruct them to stop taking RYBELSUS and seek medical advice promptly if such symptoms occur [see Warnings and Precautions (5.7)]

Therefore, despite our efforts to adjust for confounding, residual confounding and model limitations remain possible

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