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More recently, the SELECT trial confirmed cardiovascular benefits of Wegovy in patients with overweight/obesity and established cardiovascular disease without diabetes, leading to its 2024 FDA indication for cardiovascular risk reduction in this population

However, the substantial budget impact of covering obesity treatments is a major concern, which given the size of the potential target patient population could even exhaust the entire Part D budget under certain scenarios

Upper arm: The outer back area of the upper arm, where there is sufficient subcutaneous tissue

This occurs because carrying excess weight increases physical and metabolic stress

Christoph Buettner, an endocrinologist at Rutgers Robert Wood Johnson Medical School, likened the phenomenon to other medical scenarios where rapid changes in the body can have unintended consequences