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[DOI] [PubMed] [Google Scholar] 288.Conceicao J., Dores J., Araujo F., Laires P.A., Carr R.D., Brodovicz K., Radican L., Nogueira A.M

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The timeline matters if youre planning for pregnancy, preparing for surgery, switching to another treatment, or waiting for side effects to fade

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Diabetes Care 30:19791987 Ahren B, Pacini G, Foley JE, Schweizer A (2005) Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year

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When a cardiologist's primary clinical mandate is preventing heart attacks and strokes, and a drug demonstrates 20% reduction in major cardiovascular events, that drug becomes a cardiovascular medicine rather than a metabolic medicine

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Managing Side Effects The same strategies work for both medications: Follow the titration schedule carefully Eat smaller, more frequent meals Avoid fatty, greasy foods Stay well hydrated Eat slowly and stop when satisfied Consider slower titration if effects are severe Cardiovascular and Metabolic Effects Both medications offer benefits beyond weight loss, though semaglutides evidence is stronger

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