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They reduce absorption unpredictably, meaning your carefully calculated retatrutide dosage may not be delivering what you think it is delivering

Severe or worsening xerostomia may indicate an underlying condition requiring investigation, such as Sjgren's syndrome, uncontrolled diabetes, or medication interactions that need addressing

While counting calories is one popular way to limit your intake, focusing on protein can work, too

The 7.2 mg dose was approved in the UK in January 2026

Special medical attention is important, among other things, in cases of: insufficiently controlled high blood pressure a history of seizures or increased seizure risk certain mental health conditions or noticeable mood symptoms regular use of other medications opioid use or a history of opioid dependence severely impaired liver or kidney function pregnancy, breastfeeding, or plans to become pregnant Patients can find more information about the tolerability of the medication on our page about side effects of Mysimba with naltrexone/bupropion