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2023;108(7):e431-e445

In mice, peripheral administration of ghrelin further enhances glucose-stimulated GLP-1 secretion and improves glucose tolerance, an effect that is blocked by pre-administration of the ghrelin receptor antagonist D-Lys GHRP6 and that is absent in GLP-1R KO mice [322]

The Cardiology Advisor reported findings that tirzepatide slows kidney decline even in people with prediabetes and overweight or obesity, not just established diabetes

Lynch TR, Xue M, Czerniak CW, Lee C, Kimble J (2022) Notch-dependent DNA cis-regulatory elements and their dose-dependent control of C

[DOI] [PubMed] [Google Scholar] 100.Shigeto M., Ramracheya R., Tarasov A.I., Cha C.Y., Chibalina M.V., Hastoy B., Philippaert K., Reinbothe T., Rorsman N., Salehi A., et al