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Regarding oral contraceptives specifically, a clinically relevant interaction with delayed gastric emptying has been documented for tirzepatide in its UK Summary of Product Characteristics (SmPC), which advises the use of a non-oral or additional contraceptive method during initiation and dose escalation

This classification differs from Alfonzos NICE (National Institute for Health and Care Excellence) guideline from the UK, where severe only starts at K = 6.5 mmol/L [9]

51 IGB decreased the incidence of metabolic syndrome from 34.8% (pre-IGB) to 11.6% at 12 months post-IGB removal

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