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Aiming for smaller, more frequent meals can also make it easier to meet protein needs without overwhelming the digestive system

Summary: GLP-1/GIP medications help reduce inflammation in metabolic organsnot autoimmune or pain-related inflammation They DO: lower CRP and related metabolic inflammatory/oxidative stress biomarkers, improve metabolic liver disease activity in steatohepatitis settings, improve cardiometabolic risk markers such as blood pressure improve kidney outcomes in high-risk CKD populations (semaglutide

Similar results were reported in STEP-HFpEF DM, which included patients with diabetes excluded in STEP-HFpEF [30]

For tirzepatide, the prescribing information does not specify a preconception interval but advises discontinuation when pregnancy is recognized

J Clin Invest 117:21552163 Shu L, Matveyenko AV, Kerr-Conte J, Cho JH, McIntosh CH, Maedler K (2009) Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function