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DPP-4 Inhibitors As mentioned above, DPP-4 inhibitors are now an established and successful class of oral anti-hyperglycaemic agents, and are firmly embedded in guidelines for treating T2DM patients without atherosclerotic cardiovascular (CV) disease (116, 117)

The clinical data showed the 4 mg group achieving 17.1% body weight reduction at 48 weeks, which already exceeds what most single-receptor GLP-1 agonists deliver at their maximum doses

Effects of Other Drugs on Metformin Table 7 shows the effect of coadministered drugs on the pharmacokinetics of metformin in adults

The evidence suggests a low frequency of serious adverse effects, and these do not impact the effectiveness of the combination

Signs Your GLP-1 May Be Imbalanced It is important to note that there is no routine clinical test to directly measure GLP-1 function in standard NHS practice
