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Since insulin therapy often indicates more advanced disease progression, greater severity, or additional comorbidities, which may lead to a higher risk of intestinal obstruction, and there was no statistically significant difference in intestinal obstruction risk between GLP-1RAs and other anti-diabetic medications (e.g., SGLT2 inhibitors, metformin, sulfonylureas, thiazolidinediones, DPP-4 inhibitors), the observed reduction relative to insulin does not necessarily suggest a protective effect of GLP-1RAs against intestinal obstruction

Novo Nordisks CEO, Lars Fruergaard Jrgensen, raised the alarm, underscoring the risks of compounded semaglutide preparations, which may not adhere to the same rigorous safety standards as commercially manufactured versions

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