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Finally, Tesofensine is safe for long-term use

[DOI] [PubMed] [Google Scholar] 18.Faurschou A, Gyldenlve M, Rohde U, Thyssen JP, Zachariae C, Skov L, et al

Among the 4 brand-name products with paragraph IV submissions, the median time from brand-name approval to first paragraph IV challenge was 6.8 years (IQR: 6.0-7.4)

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There's research suggesting an association between estrogen and cognitive function, and the timing hypothesis is relevant here too: early initiation of HRT is studied differently than late initiation for cognitive outcomes
