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Sublingual (under-the-tongue) GLP-1 agonists, such as semaglutide, represent a novel approach, promising similar benefits to injectable versions without the need for needles

CVD: Cardiovascular Disease Although several in-line GLP-1 and glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 RAs have approved indications beyond T2D and overweight/ obesity, US Pharmacopeia Drug Classification (USP DC) 2025 limits classification to categories/classes according to their primary diagnosis (e.g., antidiabetic

Chrousos, G

it is prescribed only when clinically appropriate and after a full evaluation of a

This suggests that systemic endothelial dysfunction may be a primary factor in the development of systemic hypertension and its pathological consequences, such as increased left ventricular wall stress, hypertrophy, diastolic dysfunction, and HFpEF [22]