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Unfortunately, it is difficult to assess potential sex differences in pharmacokinetics and tolerability of, for example, semaglutide, as a large fraction of the available data was either tested exclusively in male human, primate, or rat subjects (82) or not presented disaggregated by sex (83, 84)

GLP-1 receptor agonists may be appropriate second-line agents after metformin or even first-line in patients with established cardiovascular disease, chronic kidney disease, or when weight management is a priority

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