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For many patients, weekly injections are generally considered the more traditional and evidence-supported route for GLP-1 weight management

Pair flavors with complementary sweeteners (e.g., allulose, monk fruit) and masking agents to maintain consumer acceptance

As in the previously mentioned study there was no difference between GLP-1 receptor agonists and SGLT2 inhibitors in reducing the risk of MACE, but when compared to DPP-4 inhibitors SGLT2 inhibitors significantly reduced cardiovascular and total death

However, in a sensitivity analysis of the REWIND study with dulaglutide, the relative risk reduction for a 40% or 50% decrease in eGFR was 30% and 44%, both significant, in the dulaglutide group compared to placebo, respectively.92 This lower risk of developing macroalbuminuria was also confirmed in an exploratory analysis of the ELIXA (lixisenatide) study.93 In the EXSCEL study (exenatide LAR), renal episodes were analyzed as additional microvascular episodes, and no differences were observed in the risk of episodes related to decreased eGFR, but differences were observed in the composite episode, which included decreased eGFR and macroalbuminuria, although only after adjustment94 (Table 2)

Similar reductions in serum LH were reported with GLP-1/GIP administration, while GLP-1/E treatment restored estrous cyclicity and increased the number of corpora lutea across multiple generations (Sanchez-Garrido et al., 2024)