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there is no medical requirement to wait or fast following your weekly dose

They act locally in the nasal passages and are not significantly absorbed systemically, so they are unaffected by bariatric surgery Eye drops containing antihistamines or mast cell stabilisers (such as sodium cromoglicate) are useful for allergic conjunctivitis and bypass absorption concerns entirely Allergen avoidance remains a cornerstone of allergy management identifying and minimising exposure to known triggers (such as pollen, dust mites, or pet dander) can reduce reliance on medication Nutritional supplementation following bariatric surgery is important for overall health and should follow BOMSS guidance on vitamins and minerals after weight loss surgery

Vtek L, Carey MC

There are many benefits to exercise on a weight loss journey and beyond

One other downside that I think you didn't point to specifically, but you meant in saying there's some unknown downside to this, there are some early studies that are showing that you lose more lean muscle mass when you're on a GLP-1 than if you were just doing diet and exercise