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In preclinical models, comparison of cotadutide, a glucagon/GLP-1 dual RA, and liraglutide demonstrated superior reduction of hepatic de novo lipogenesis and enhancement of hepatocyte mitochondrial oxidative capacity (similar to levels stimulated by glucagon mono-agonismsuggesting restoration of mitochondrial function is a glucagon-specific benefit) [39]

It is administered as a subcutaneous injection once weekly, with available doses of 0.75 mg, 1.5 mg, 3 mg, and 4.5 mg (Table 1)

When patients understand the connection between metabolic health and reproductive function, they are more likely to stay engaged in treatment

Bull Acad R Med Belg 12, 620634 (1932)

Eduardo Grunvald, M.D., FACP, Medical Director of the University of California San Diego Center for Advanced Weight Management, though he points out that the benefits of treating obesity outweigh that risk