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This is the window where timing strategy matters most, and where evening injection provides the biggest advantage for those who struggle with nausea

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Group, Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naive patients with type 2 diabetes (DURATION-4): a 26-week double-blind study, Diabetes care, 35 (2012) 252258

On the other hand, processes specific to the secondary network involved 30 genes related to the Parkin-Ubiquitin Proteasomal System pathway (PSMD10, PSMD12, PSMD11, PSMD14, TUBAL3, HSPA1L, PSMD13, HSPA6, UBE2J2, HSPA14, PSMD8, PSMD7, PSMD4, PSMC3, PSMC4, PSMC1, PSMD3, PSMC2, PSMD1, UBA1), Striated Muscle Contraction Pathway, genes associated with Genome Maintenance, oxidative stress, and hypoxia-related terms (Fig

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