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Oral semaglutide is already available, and oral tirzepatide is in development

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Jin M, Zhang S, Huang B, Li L, Liang H, Ni A, et al

Importantly, the receptor for GLP-1 (GLP-1R) is abundantly expressed by vagal afferents 12,26,27 and physiological studies indicate that peripheral nerves are, at least in part, necessary for both endogenous GLP-1 and administered GLP-1 receptor agonists satiating and incretin effects 12,28,29,30,31,32